.png)
Prenatal TMS
Research supports TMS as a promising treatment option for depression during pregnancy, particularly for patients seeking to avoid or minimize medication exposure. Clinical trials, including a randomized controlled trial and open-label studies in pregnant women with major depressive disorder, have demonstrated meaningful reductions in depressive symptoms with goodtolerability [1] [2].
Systematic reviews and meta-analyses similarly report significant symptom improvement and reassuring maternal and fetal safety data, with no serious adverse obstetric or neonatal outcomes identified in the availableliterature [3] [4].
While larger studies are ongoing, current evidence suggests that TMS is a viable and well-tolerated non-pharmacologic treatment during pregnancy.
Postpartum TMS
TMS has also shown effectiveness for depression in the postpartum period, where untreated symptoms can significantly affect maternal functioning and infant bonding. Reviews of peripartum populations, including postpartum patients, demonstrate significant reductions in depressive symptoms and favorable tolerabilityprofiles [3] [5].
Importantly, because TMS is not a systemic medication, it does not transfer into breast milk, making it an appealing option for breastfeeding mothers. Emerging literature continues to support TMS as a safe and effective treatment for postpartum depression, expanding access to non-medication-based care during this criticalperiod [4] [5].
One-D Protocol
(Single-Day Accelerated TMS)
20 treatments in 1 day
10-hour treatment day
What This Means
Our One-Day Protocol is our most compressed treatment option, delivering 20 treatments in a single day.
This approach is based on emerging accelerated-TMS research associated with Jonathan Downar MD and colleagues [3]. It is designed for carefully selected patients after a thorough clinical evaluation.
How This Is Different From Standard TMS
Standard TMS is delivered:
-
once per day
-
over 6–8 weeks
The 1-Week Accelerated option:
-
delivers multiple treatments per day
-
completes treatment in 5 days
The One-Day Protocol:
-
delivers multiple treatments in a single day
-
completes treatment in one visit
All three approaches use TMS — the difference is how treatment is scheduled.
Who This May Be a Good Fit For
This may be a good fit for patients who:
-
are seeking the most time-efficient option
-
are traveling from farther away
-
cannot realistically attend repeated visits
-
want to explore an ultra-compressed treatment schedule
-
understand this is a more specialized pathway
What the Treatment Day Looks Like
-
multiple treatment sessions throughout the day
-
breaks between sessions
-
approximately 10 hours total
-
patients remain awake and alert
What Patients Often Consider
-
Time
Completed in one day. -
Travel
Often chosen by patients coming from out of town. -
Intensity
More concentrated than other treatment options. -
Structure
Fewer total treatments than standard TMS protocols.
How is this different from 1-week accelerated TMS?
The One-D Protocol delivers fewer treatments in a single day, while the 1-week option delivers a full course over 5 days [3].
Is this the same as SAINT?
Not necessarily. SAINT helped bring attention to accelerated TMS, but not every accelerated protocol is the same [4].
Is this right for everyone?
No. This is a more specialized pathway and requires clinical evaluation.
Sources
-
Blumberger DM, Vila-Rodriguez F, Thorpe KE, et al. Effectiveness of theta burst versus high-frequency repetitive transcranial magnetic stimulation in patients with depression (THREE-D): a randomized non-inferiority trial. The Lancet. 2018;391(10131):1683-1692.
-
Luehr J, et al. Pragmatic accelerated transcranial magnetic stimulation: delivering 36 treatments in 5 days. 2024.
-
Downar J, et al. Accelerated transcranial magnetic stimulation delivered in a single day (ONE-D protocol): case series and emerging evidence. 2025.
-
Cole EJ, Stimpson KH, Bentzley BS, et al. Stanford accelerated intelligent neuromodulation therapy for treatment-resistant depression (SAINT). American Journal of Psychiatry. 2020;177(8):716-726.
Before TMS, life felt dark and heavy. I was just going through the motions.
After treatment, my thoughts became lighter and I found motivation again.
The change was worth it.
Before TMS, I felt hopeless and defeated. I was sleeping too much and withdrawing from life.
Now I feel hopeful and excited about the future. I’ve started reading again and re-engaging with life.
TMS was effective and life-changing.
Before TMS, life felt slow and hopeless.
After treatment, I feel happier, more outgoing, and able to get out of bed and live my day.
I could truly feel the improvement.
