1-Week Accelerated

Prenatal TMS

Research supports TMS as a promising treatment option for depression during pregnancy, particularly for patients seeking to avoid or minimize medication exposure. Clinical trials, including a randomized controlled trial and open-label studies in pregnant women with major depressive disorder, have demonstrated meaningful reductions in depressive symptoms with goodtolerability [1] [2].

Systematic reviews and meta-analyses similarly report significant symptom improvement and reassuring maternal and fetal safety data, with no serious adverse obstetric or neonatal outcomes identified in the availableliterature [3] [4].

While larger studies are ongoing, current evidence suggests that TMS is a viable and well-tolerated non-pharmacologic treatment during pregnancy.

Postpartum TMS

TMS has also shown effectiveness for depression in the postpartum period, where untreated symptoms can significantly affect maternal functioning and infant bonding. Reviews of peripartum populations, including postpartum patients, demonstrate significant reductions in depressive symptoms and favorable tolerabilityprofiles [3] [5].

Importantly, because TMS is not a systemic medication, it does not transfer into breast milk, making it an appealing option for breastfeeding mothers. Emerging literature continues to support TMS as a safe and effective treatment for postpartum depression, expanding access to non-medication-based care during this criticalperiod [4] [5].

A full course of TMS,

delivered in one week.

36 treatments in 5 days
Up to 8 hours per day

What This Means

Our 1-Week Accelerated option compresses a full standard course of TMS into one week by delivering multiple treatments per day.

This approach follows the growing literature on accelerated TMS and the pragmatic model described by Luehr et al.[2] — taking the familiar 36-treatment course and delivering it in a shorter timeframe. At New Chapter, we use FDA-cleared standard 20-minute treatments in this accelerated format.

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How This Is Different From Standard TMS

For Your Baby

Standard TMS is delivered:

once per day
over 6–8 weeks
in sessions lasting less than 20 minutes

The 1-Week Accelerated option:

delivers multiple treatments per day
maintains the same total number of treatments
completes treatment in 5 days

The treatment itself is the same, the difference is how it is scheduled [1][2].

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Who This May Be a Good Fit For

This may be a good fit for patients who:

want a faster treatment timeline
cannot realistically attend 6–8 weeks of daily visits
are traveling for treatment
want an evidence-informed accelerated option

What a Treatment Week Looks Like

multiple treatment sessions per day
breaks between sessions
up to ~8 hours per day
completed over 5 consecutive days

While the days are longer, the overall course is completed in a single week.

What Patients Often Consider

Time

Shorter overall timeline compared to standard TMS.

Travel

Many patients choose this option when traveling, as it allows treatment to be completed in one week rather than returning daily for several weeks.

Pacing

Treatment days are longer, but the overall time commitment is condensed.

Structure

This option maintains the full 36-treatment protocol used in standard TMS.

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Is 1-week accelerated TMS as effective as standard TMS?

This approach delivers the same total number of treatments as standard TMS, just in a shorter timeframe [2].

Is it more intense than standard TMS?

Yes. Because multiple treatments are delivered per day, treatment days are longer—but the overall course is much shorter.

Is this the same as SAINT?

Not necessarily. SAINT helped bring attention to accelerated TMS, but not every accelerated protocol is the same [4].

Do I need to travel for this option?

Some patients choose this approach specifically because it allows them to complete treatment in a single week rather than returning daily for several weeks.

New Connections, New Hope

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Sources

Blumberger DM, Vila-Rodriguez F, Thorpe KE, et al. Effectiveness of theta burst versus high-frequency repetitive transcranial magnetic stimulation in patients with depression (THREE-D): a randomized non-inferiority trial. The Lancet. 2018;391(10131):1683-1692.
Luehr J, et al. Pragmatic accelerated transcranial magnetic stimulation: delivering 36 treatments in 5 days. 2024.
Downar J, et al. Accelerated transcranial magnetic stimulation delivered in a single day (ONE-D protocol): case series and emerging evidence. 2025.
Cole EJ, Stimpson KH, Bentzley BS, et al. Stanford accelerated intelligent neuromodulation therapy for treatment-resistant depression (SAINT). American Journal of Psychiatry. 2020;177(8):716-726.